Synapse elimination and learning rules coregulated by MHC Class I H2-Db

@inproceedings{Lee2014SynapseEA,
  title={Synapse elimination and learning rules coregulated by MHC Class I H2-Db},
  author={Hanmi Lee and Lowry A Kirkby and Barbara K. Brott and Jaimie D Adelson and Sarah Cheng and Marla B Feller and Akash Datwani and Carla J. Shatz},
  booktitle={Nature},
  year={2014}
}
The formation of precise connections between retina and lateral geniculate nucleus (LGN) involves the activity-dependent elimination of some synapses, with strengthening and retention of others. Here we show that the major histocompatibility complex (MHC) class I molecule H2-Db is necessary and sufficient for synapse elimination in the retinogeniculate… CONTINUE READING