Synapse-Specific, Long-Term Facilitation of Aplysia Sensory to Motor Synapses: A Function for Local Protein Synthesis in Memory Storage

@article{Martin1997SynapseSpecificLF,
  title={Synapse-Specific, Long-Term Facilitation of Aplysia Sensory to Motor Synapses: A Function for Local Protein Synthesis in Memory Storage},
  author={Kelsey C Martin and Andrea Casadio and Huixiang Zhu and E Yaping and Jack C Rose and Mary C. Chen and Craig H. Bailey and Eric R. Kandel},
  journal={Cell},
  year={1997},
  volume={91},
  pages={927-938}
}
The requirement for transcription during long-lasting synaptic plasticity has raised the question of whether the cellular unit of synaptic plasticity is the soma and its nucleus or the synapse. To address this question, we cultured a single bifurcated Aplysia sensory neuron making synapses with two spatially separated motor neurons. By perfusing serotonin onto the synapses made onto one motor neuron, we found that a single axonal branch can undergo long-term branch-specific facilitation. This… Expand

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  • K. Martin
  • Biology, Medicine
  • Neurobiology of Learning and Memory
  • 2002
TLDR
This review describes the studies of synapse-specific, transcription-dependent facilitation of cultured Aplysia sensory-motor synapse in the context of the synaptic tagging hypothesis and describes the results. Expand
Coincident Induction of Long-Term Facilitation at Sensory-Motor Synapses in Aplysia: Presynaptic and Postsynaptic Factors
TLDR
If Aplysia sensory neuron (SN) somata and their remote motor neuron (MN) synapses are simultaneously exposed to serotonin (5HT) pulses, processes activated at these sites interact to induce LTF, which differs mechanistically from coincident LTF. Expand
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TLDR
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  • Biology, Medicine
  • Neuroscience and Behavioral Physiology
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Synapse- and Stimulus-Specific Local Translation During Long-Term Neuronal Plasticity
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It is demonstrated, using translational reporters of sensorin mRNA expressed in individual cultured Aplysia sensory and motor neurons, that local translation occurs at synapses during transcription-dependent, learning-related forms of synaptic plasticity. Expand
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A role for the importin family of nuclear transporters in carrying signals from synapses to the nucleus during long-term plasticity is discovered and hundreds of mRNAs that are present in distal processes of Aplysia neurons and in dendrites of rodent hippocampal neurons are identified. Expand
A New Component in Synaptic Plasticity: Upregulation of Kinesin in the Neurons of the Gill-Withdrawal Reflex
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It is found that the induction of long-term facilitation by repeated applications of serotonin, a modulatory transmitter released during learning in Aplysia, requires upregulation of kinesin heavy chain (KHC) in both pre- and postsynaptic neurons. Expand
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