SynLethDB: synthetic lethality database toward discovery of selective and sensitive anticancer drug targets

@article{Guo2016SynLethDBSL,
  title={SynLethDB: synthetic lethality database toward discovery of selective and sensitive anticancer drug targets},
  author={Jing Guo and Hui Liu and Jie Zheng},
  journal={Nucleic acids research},
  year={2016},
  volume={44 D1},
  pages={
          D1011-7
        }
}
Synthetic lethality (SL) is a type of genetic interaction between two genes such that simultaneous perturbations of the two genes result in cell death or a dramatic decrease of cell viability, while a perturbation of either gene alone is not lethal. SL reflects the biologically endogenous difference between cancer cells and normal cells, and thus the inhibition of SL partners of genes with cancer-specific mutations could selectively kill cancer cells but spare normal cells. Therefore, SL is… CONTINUE READING
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