Symptoms of Obstructive Sleep Apnea in Patients with Nonalcoholic Fatty Liver Disease

@article{Singh2005SymptomsOO,
  title={Symptoms of Obstructive Sleep Apnea in Patients with Nonalcoholic Fatty Liver Disease},
  author={Harminder Singh and R. Pollock and J. Uhanova and M. Kryger and K. Hawkins and G. Minuk},
  journal={Digestive Diseases and Sciences},
  year={2005},
  volume={50},
  pages={2338-2343}
}
Nonalcoholic fatty liver disease (NAFLD) is a term often used to describe two related conditions: a relatively benign, nonalcoholic fatty liver (NAFL) and potentially aggressive, nonalcoholic steatohepatitis (NASH). Both conditions (NAFL and NASH) occur in the setting of peripheral insulin resistance. Recently, obstructive sleep apnea (OSA) has been proposed as an independent risk factor for insulin resistance. To date, few studies have documented the prevalence of OSA or symptoms of OSA (SOSA… Expand
Nonalcoholic Fatty Liver Disease Associated with Obstructive Sleep Apnea: Just a Coincidence?
TLDR
Obese patients had elevated OSA and NAFLD frequencies and OSA was associated with insulin resistance but not with the severity of NASH, but no association was found between AHI and NASH. Expand
Obstructive sleep apnoea and nonalcoholic fatty liver disease: risk factor or just coincidence?
TLDR
The association of polysomnography parameters and histological subtypes of NAFLD as well as hepatic fibrosis was evaluated, suggesting that oxygen desaturation during sleep is a risk for developing steatohepatitis, especially in patients with underlying hepatic steatosis. Expand
Obstructive Sleep Apnea and Non-Alcoholic Fatty Liver Disease: Is the Liver Another Target?
TLDR
Multiple lines of evidence suggest that IH of OSA may contribute to the progression of NAFLD but definitive clinical studies and experiments in the mouse model have yet to be done. Expand
Obstructive sleep apnea is an important predictor of hepatic fibrosis in patients with nonalcoholic fatty liver disease in a tertiary care center
TLDR
Prevalence of symptomatic OSA in patients with NAFLD is low and is predicted by male gender and obesity, while significant hepatic fibrosis in Patients with NA FLD is predictedBy OSA independent of obesity and metabolic syndrome. Expand
Obstructive Sleep Apnea Is Associated with Liver Damage and Atherosclerosis in Patients with Non-Alcoholic Fatty Liver Disease
TLDR
To consider sleep disordered breathing as a potential additional therapeutic target in severe NAFLD patients with chronically elevated ALT at low prevalence of morbid obesity, OSA was highly prevalent and indexes of SaO2 resulted independently associated with severity of liver fibrosis and carotid atherosclerosis. Expand
Association between nocturnal hypoxia and liver injury in the setting of nonalcoholic fatty liver disease
TLDR
OSA-related hypoxia was independently associated with the biochemical evidence of liver injury in the presence of NAFLD, and oxygen desaturation index was the major contributing factor for elevated ALT. Expand
Obstructive Sleep Apnea Is Associated with Fatty Liver and Abnormal Liver Enzymes: a Meta-analysis
TLDR
Routine assessment of liver enzymes and liver damage should be implemented in OSA patients because they have an increase of 13.3% of ALT and 4.4% of AST levels, and a 2.6-fold higher risk of liver fibrosis when they have nonalcoholic fatty liver disease. Expand
Risk of Obstructive Sleep Apnea with Daytime Sleepiness Is Associated with Liver Damage in Non-Morbidly Obese Patients with Nonalcoholic Fatty Liver Disease
TLDR
A proportion of NAFLD patients without severe obesity is at risk for OSAS with daytime sleepiness, which is associated with the severity of liver damage independently of body mass and other cofactors. Expand
Obstructive sleep apnea with excessive daytime sleepiness is associated with non-alcoholic fatty liver disease regardless of visceral fat
TLDR
In the present study, OSA was closely associated with NAFLD in Korean adults, particularly strong in those with EDS or short sleep duration regardless of VFA. Expand
The influence of obstructive sleep apneao–induced intermittant Hypoxia on Non Alcoholic Fatty liver
TLDR
Patients with severe nocturnal hypoxemia should be closely assessed for development of NAFLD and those with OSA and a suspicion of hepatosteatosis should have liver ultrasonography. Expand
...
1
2
3
4
5
...

References

SHOWING 1-10 OF 38 REFERENCES
Fatty liver hepatitis (steatohepatitis) and obesity: An autopsy study with analysis of risk factors
TLDR
Statohepatitis (fatty liver hepatitis), histologically identical to alcoholic disease, occurs in some obese patients after jejunoileal bypass, and incidence of steatosis and steatohePatitis correlated with the degree of obesity. Expand
Obstructive sleep apnea is independently associated with insulin resistance.
TLDR
The findings suggest that OSA is independently associated with insulin resistance, and its role in the atherogenic potential of sleep disordered breathing is worthy of further exploration. Expand
Effects of obstructive sleep apnea syndrome on serum aminotransferase levels in obese patients.
TLDR
Nasal CPAP therapy may have beneficial effects on serum aminotransferase abnormalities in obese patients who have obstructive sleep apnea. Expand
The prevalence of obstructive sleep apnoea in an obese female population.
TLDR
The findings indicate that over one third of women had OSA, yet they did not complain of symptoms even though the PSQI questionnaire indicated that they were poor sleepers, and obese women should be considered at risk of OSA. Expand
Obstructive sleep apnea in obese noninsulin-dependent diabetic patients: effect of continuous positive airway pressure treatment on insulin responsiveness.
TLDR
The results indicate that OSA occurs commonly in obese NIDDM patients with excessive sleepiness or heavy snoring, and treatment of their OSA may improve insulin responsiveness. Expand
Obesity and obstructive sleep apnea.
TLDR
Common diseases and disease mechanisms in OSA and obesity suggest that conditions related to obesity may be better managed if patients, particularly those who are morbidly obese, are evaluated and treated for previously undiagnosed OSA. Expand
Metabolic correlates with obstructive sleep apnea in obese subjects.
TLDR
The severity of OSA (log(10)RDI) correlated with fasting insulin levels, independent of BMI, and insulin levels may be further elevated as a consequence of Osa in obese children. Expand
Using the Berlin Questionnaire To Identify Patients at Risk for the Sleep Apnea Syndrome
TLDR
The Berlin Questionnaire was evaluated for the usefulness of this instrument in identifying patients with sleep apnea in primary care settings and was shown to be useful in sleep clinic and community surveys. Expand
Sleep apnea and sleep disruption in obese patients.
TLDR
Severely or morbidly obese men are at extremely high risk for sleep apnea and should be routinely evaluated in the sleep laboratory for this condition, while for severely or morbidley obese women the physician should include a thorough sleep history in the clinical assessment. Expand
Evidence for lipid peroxidation in obstructive sleep apnea.
TLDR
The results support the existence of an increased state of oxidative stress in OSA and its possible involvement in cardiovascular morbidity. Expand
...
1
2
3
4
...