Symptoms in patients with ulcerative colitis in remission are associated with visceral hypersensitivity and mast cell activity.

@article{Hoboken2011SymptomsIP,
  title={Symptoms in patients with ulcerative colitis in remission are associated with visceral hypersensitivity and mast cell activity.},
  author={Eduard A van Hoboken and Annemieke Y Thijssen and Rob Verhaaren and Patrick P. J. van der Veek and Frans A. Prins and Hein W. Verspaget and Ad Am Masclee},
  journal={Scandinavian journal of gastroenterology},
  year={2011},
  volume={46 7-8},
  pages={981-7}
}
OBJECTIVE Patients with ulcerative colitis in remission (UCR) frequently report irritable bowel syndrome (IBS)-like symptoms. Recent studies have pointed to the role of mast cells in mediating visceral hypersensitivity in IBS. We hypothesized that visceral hypersensitivity is frequently present in patients with UCR and is related to the quantity and activity of mast cells in the sigmoid mucosa. MATERIAL AND METHODS A group of 17 controls and 19 patients with UCR were studied. Rectal… CONTINUE READING
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