Symptomatic hypoglycemia in children receiving oral purine analogues for treatment of childhood acute lymphoblastic leukemia.

@article{Ziino2002SymptomaticHI,
  title={Symptomatic hypoglycemia in children receiving oral purine analogues for treatment of childhood acute lymphoblastic leukemia.},
  author={Ottavio Ziino and Delia Russo and Maria Antonietta Orlando and Vincenzo Benigno and Franco Locatelli and M. Rita Aric{\`o}},
  journal={Medical and pediatric oncology},
  year={2002},
  volume={39 1},
  pages={32-4}
}
BACKGROUND Antimetabolite-based continuation therapy is commonly used for childhood acute lymphoblastic leukemia (ALL) and hypoglycemia after prolonged fasting has been recently reported. We have found that spontaneous, symptomatic hypoglycemia (SH) may also occur in such patients. PROCEDURE Between 1995 and 1999, patients treated according to the AIEOP-ALL-95 study received BFM-type intensive chemotherapy; mercaptopurine (6-MP) was given (60 mg/m(2)/days, orally for 14 days) during the… CONTINUE READING