Symptom reduction and suicide risk in patients treated with placebo in antidepressant clinical trials: a replication analysis of the Food and Drug Administration Database.

@article{Khan2001SymptomRA,
  title={Symptom reduction and suicide risk in patients treated with placebo in antidepressant clinical trials: a replication analysis of the Food and Drug Administration Database.},
  author={Arif Khan and Shirin R F Khan and Robyn M Leventhal and W. A. Brown},
  journal={The international journal of neuropsychopharmacology},
  year={2001},
  volume={4 2},
  pages={113-8}
}
The assumption that depressed patients who are assigned to placebo in antidepressant clinical trials are exposed to substantial morbidity and mortality has not been based on research data. Because of worldwide concern about placebo use and the implications of our earlier findings of no increased suicide risk in placebo-treated patients, we conducted a replication study in a new patient sample. We assessed suicide risk and symptom reduction among placebo-treated patients participating in… CONTINUE READING

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