Symptom pathogenesis during acute influenza: interleukin-6 and other cytokine responses.

  title={Symptom pathogenesis during acute influenza: interleukin-6 and other cytokine responses.},
  author={Laurent Kaiser and Richard Fritz and Stephen E. Straus and Larisa V. Gubareva and Frederick G. Hayden},
  journal={Journal of medical virology},
  volume={64 3},
In experimental human influenza infection initiated by nasal inoculation, the magnitude of viral replication, fever, and symptoms correlate with nasopharyngeal lavage fluid levels of various cytokines. Our aim was to assess these relationships in patients with naturally occurring acute influenza. Patients with culture-positive influenza illness of less than 36 hr of duration were studied. Nasopharyngeal washing were collected at enrollment and on Day 2, 4, 6 and 8 for quantitative virus… CONTINUE READING


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