Symptom control in cancer patients: the clinical pharmacology and therapeutic role of suppositories and rectal suspensions

@article{Davis2001SymptomCI,
  title={Symptom control in cancer patients: the clinical pharmacology and therapeutic role of suppositories and rectal suspensions},
  author={Mellar P. Davis and Declan Walsh and Susan B Legrand and Michael Naughton},
  journal={Supportive Care in Cancer},
  year={2001},
  volume={10},
  pages={117-138}
}
Abstract Rectally administered medications are essential in palliative medicine, particularly in the last days of life. They are underutilized. The pharmacology of rectally administered medications relates not only to the medication but also to the suppository base, additives, drug ionization, pKa, absorptive surface of the rectum, and rectal health. The pharmacokinetics may differ from those of orally administered medications owing to reduced hepatic first-pass clearance. In this review the… 
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Considering that the rectal route might eliminate the time-dependent changes of valproic acid kinetics and starting from the need to develop suppositories for paediatric use, in our previous studies
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