Symposium: Assembly and Physiology of Apolipoprotein B–Containing Lipoproteins: Not Just for Heart Disease Anymore! Assembly of Very Low Density Lipoprotein: A Two-Step Process of Apolipoprotein B Core Lipidation

Abstract

The liver plays a primary role in lipid metabolism. Important functions include the synthesis and incorporation of hydrophobic lipids, triacylglycerols and cholesteryl esters into the core of water-miscible particles called lipoproteins and the secretion of these particles into the circulation for transport to distant tissues. In this article, we present a brief overview of one aspect of the assembly process of very low density lipoproteins, namely, possible mechanisms for combining core lipids with apolipoprotein B. This is a complex process in which apolipoprotein B interacts with core lipids to form very low density lipoproteins by a two-step process that can be dissociated biochemically. J. Nutr. 129: 463S–466S, 1999.

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@inproceedings{Rustaeus1999SymposiumAA, title={Symposium: Assembly and Physiology of Apolipoprotein B–Containing Lipoproteins: Not Just for Heart Disease Anymore! Assembly of Very Low Density Lipoprotein: A Two-Step Process of Apolipoprotein B Core Lipidation}, author={Sabina Rustaeus and Karin Lindberg and Pia Stillemark and Catharina Claesson and Lennart Asp and Thomas B. Larsson and Jan Bor{\'e}n and S O Olofsson}, year={1999} }