Corpus ID: 36834681

Symposium 6 : Adipose tissue – liver – muscle interactions leading to insulin resistance Metabolic flexibility

  title={Symposium 6 : Adipose tissue – liver – muscle interactions leading to insulin resistance Metabolic flexibility},
  author={L. Storlien and N. Oakes and D. Kelley},
Human physiology needs to be well adapted to cope with major discontinuities in both the supply of and demand for energy. This adaptability requires ‘a clear capacity to utilize lipid and carbohydrate fuels and to transition between them’ (Kelley et al. 2002b). Such capacities characterize the healthy state and can be termed ‘metabolic flexibility’. However, increasing evidence points to metabolic inflexibility as a key dysfunction of the cluster of disease states encompassed by the term… Expand
3 Citations


Adipose tissue as a buffer for daily lipid flux
  • K. Frayn
  • Medicine, Biology
  • Diabetologia
  • 2002
  • 631
  • Highly Influential
  • PDF
Fuel selection in human skeletal muscle in insulin resistance: a reexamination.
  • 878
  • PDF
Muscle triglyceride and insulin resistance.
  • 309
Skeletal muscle fatty acid metabolism in association with insulin resistance, obesity, and weight loss.
  • 937
Dysfunction of mitochondria in human skeletal muscle in type 2 diabetes.
  • 1,989
  • PDF
Response of adipose tissue lipoprotein lipase to the cephalic phase of insulin secretion.
  • 87
Adipose tissue metabolism in obesity: lipase action in vivo before and after a mixed meal.
  • 263
Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1
  • M. Patti, A. Butte, +14 authors L. Mandarino
  • Biology, Medicine
  • Proceedings of the National Academy of Sciences of the United States of America
  • 2003
  • 1,818
  • Highly Influential
  • PDF
Mitochondrial Dysfunction in the Elderly: Possible Role in Insulin Resistance
  • 1,830
Acquirement of Brown Fat Cell Features by Human White Adipocytes*
  • 433