Sympathetic stimulation of adult cardiomyocytes requires association of AKAP5 with a subpopulation of L-type calcium channels.

@article{Nichols2010SympatheticSO,
  title={Sympathetic stimulation of adult cardiomyocytes requires association of AKAP5 with a subpopulation of L-type calcium channels.},
  author={Connie B Nichols and Charles F. Rossow and Manuel F. Navedo and Ruth E. Westenbroek and William A. Catterall and L Fernando Santana and G Stanley McKnight},
  journal={Circulation research},
  year={2010},
  volume={107 6},
  pages={747-56}
}
RATIONALE Sympathetic stimulation of the heart increases the force of contraction and rate of ventricular relaxation by triggering protein kinase (PK)A-dependent phosphorylation of proteins that regulate intracellular calcium. We hypothesized that scaffolding of cAMP signaling complexes by AKAP5 is required for efficient sympathetic stimulation of calcium transients. OBJECTIVE We examined the function of AKAP5 in the β-adrenergic signaling cascade. METHODS AND RESULTS We used calcium… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 62 extracted citations

Function of Adenylyl Cyclase in Heart: the AKAP Connection

Journal of cardiovascular development and disease • 2018
View 13 Excerpts
Highly Influenced

Role of plasma membrane-associated AKAPs for the regulation of cardiac IK1 current by protein kinase A

Naunyn-Schmiedeberg's Archives of Pharmacology • 2017
View 13 Excerpts
Highly Influenced

Cardiac voltage-gated calcium channel macromolecular complexes.

Biochimica et biophysica acta • 2016
View 10 Excerpts
Highly Influenced

Anchored protein kinase A signalling in cardiac cellular electrophysiology

Journal of cellular and molecular medicine • 2014
View 3 Excerpts
Highly Influenced

A-kinase anchoring proteins: scaffolding proteins in the heart.

American journal of physiology. Heart and circulatory physiology • 2011
View 9 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 13 references

Adenylyl cyclase type 5 protein expression during cardiac development and stress.

American journal of physiology. Heart and circulatory physiology • 2009

Cell-type-specific isolation of ribosome-associated mRNA from complex tissues.

Proceedings of the National Academy of Sciences of the United States of America • 2009

Similar Papers

Loading similar papers…