Sympathetic reactivity of cerebral arteries in developing fetal lamb and adult sheep.

@article{Wagerle1990SympatheticRO,
  title={Sympathetic reactivity of cerebral arteries in developing fetal lamb and adult sheep.},
  author={Lorin Craig Wagerle and Charles Dean Kurth and Robert A. Roth},
  journal={The American journal of physiology},
  year={1990},
  volume={258 5 Pt 2},
  pages={H1432-8}
}
The response of cerebral arteries to norepinephrine was examined in vivo in six dated preterm fetal (94-121 days gestation), eight term fetal (127-141 days gestation), five newborn (7-14 days), and five adult sheep, anesthetized and equipped with a closed cranial window. Norepinephrine (10(-8)-10(-4) M in cerebrospinal fluid) caused a dose-dependent decrease in pial arteriolar diameter in fetal and newborn lambs; however, preterm fetuses were 7- and 14-fold more sensitive to norepinephrine than… CONTINUE READING

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