Sympathetic pathways mediate GLP-1 actions in the gastrointestinal tract of the rat.

@article{Giralt1998SympatheticPM,
  title={Sympathetic pathways mediate GLP-1 actions in the gastrointestinal tract of the rat.},
  author={Magda Giralt and Patricia Vergara},
  journal={Regulatory peptides},
  year={1998},
  volume={74 1},
  pages={19-25}
}
The aim of this study was to establish the actions of GLP-1 (7-37) on gastrointestinal motility in rats. We prepared anaesthetized Sprague-Dawley rats with strain-gauges in the antrum, duodenum and the proximal jejunum and a catheter in the aorta close to the coeliac artery for close infusion of substances. Intraarterial GLP-1 infusions (3 x 10(-10) and 3 x 10(-9) moles/kg per 10 min) (n = 8) induced inhibition of spontaneous motor activity in the antrum, duodenum and proximal jejunum… CONTINUE READING
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