Sympathetic overactivity precedes metabolic dysfunction in a fructose model of glucose intolerance in mice.

@article{Angelis2012SympatheticOP,
  title={Sympathetic overactivity precedes metabolic dysfunction in a fructose model of glucose intolerance in mice.},
  author={K{\'a}tia De Angelis and Danielle D Senador and Cristiano Texeira Mostarda and Maria Cl{\'a}udia Costa Irigoyen and Mariana Morris},
  journal={American journal of physiology. Regulatory, integrative and comparative physiology},
  year={2012},
  volume={302 8},
  pages={R950-7}
}
Consumption of high levels of fructose in humans and animals leads to metabolic and cardiovascular dysfunction. There are questions as to the role of the autonomic changes in the time course of fructose-induced dysfunction. C57/BL male mice were given tap water or fructose water (100 g/l) to drink for up to 2 mo. Groups were control (C), 15-day fructose (F15), and 60-day fructose (F60). Light-dark patterns of arterial pressure (AP) and heart rate (HR), and their respective variabilities were… CONTINUE READING
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