Sympathetic noradrenergic before striatal dopaminergic denervation: relevance to Braak staging of synucleinopathy

@article{Goldstein2011SympatheticNB,
  title={Sympathetic noradrenergic before striatal dopaminergic denervation: relevance to Braak staging of synucleinopathy},
  author={David S Goldstein and Courtney Holmes and Latoya Sewell and Mee Yeong Park and Yehonatan Sharabi},
  journal={Clinical Autonomic Research},
  year={2011},
  volume={22},
  pages={57-61}
}
Braak’s staging concept of Lewy body disease pathogenesis is based on a spatiotemporal sequence of alpha-synuclein deposition, with autonomic nervous system involvement before synucleinopathy in substantia nigra neurons. A patient with primary chronic autonomic failure underwent biennial brain 6-[18F]DOPA and myocardial 6-[18F]dopamine scanning over 4 years. Low myocardial radioactivity indicated cardiac noradrenergic denervation that persisted. Striatal 6-[18F]DOPA-derived radioactivity… CONTINUE READING

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