Sympathetic neuron–associated macrophages contribute to obesity by importing and metabolizing norepinephrine

@article{Pirzgalska2017SympatheticNM,
  title={Sympathetic neuron–associated macrophages contribute to obesity by importing and metabolizing norepinephrine},
  author={Roksana M. Pirzgalska and Elsa Seixas and Jason S Seidman and Verena M Link and Noelia Mart{\'i}nez S{\'a}nchez and In{\^e}s Mah{\'u} and Raquel C. Mendes and Vitka Gres and Nadiya Kubasova and Imogen Morris and Bernardo Assein Ar{\'u}s and Chelsea M Larabee and Miguel Vasques and Francisco M Tortosa and Ana Sousa and Sathyavathy Anandan and Erin M Tranfield and Maureen K. Hahn and Matteo Iannacone and Nathanael J. Spann and Christopher K. Glass and Ana I. Domingos},
  journal={Nature Medicine},
  year={2017},
  volume={23},
  pages={1309-1318}
}
The cellular mechanism(s) linking macrophages to norepinephrine (NE)-mediated regulation of thermogenesis have been a topic of debate. Here we identify sympathetic neuron–associated macrophages (SAMs) as a population of cells that mediate clearance of NE via expression of solute carrier family 6 member 2 (SLC6A2), an NE transporter, and monoamine oxidase A (MAOA), a degradation enzyme. Optogenetic activation of the sympathetic nervous system (SNS) upregulates NE uptake by SAMs and shifts the… CONTINUE READING
Related Discussions
This paper has been referenced on Twitter 153 times. VIEW TWEETS

Citations

Publications citing this paper.
Showing 1-10 of 14 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 45 references

Similar Papers

Loading similar papers…