Sympathetic nervous system control of anti-influenza CD 8 T cell responses

@inproceedings{Grebe2009SympatheticNS,
  title={Sympathetic nervous system control of anti-influenza CD 8 T cell responses},
  author={Kristie M. Grebe and Heather D. Hickman and Kari R. Irvine and Kazuyo Takeda and Jack R. Bennink and Jonathan W. Yewdell},
  year={2009}
}
Despite the longstanding appreciation of communication between the nervous and the immune systems, the nature and significance of these interactions to immunity remain enigmatic. Here, we show that 6-hydroxydopamine-mediated ablation of the mouse peripheral sympathetic nervous system increases primary CD8 T cell responses to viral and cellular antigens presented by direct priming or crosspriming. The sympathetic nervous system also suppresses antiviral CD4 T cell responses, but this is not… CONTINUE READING