Sympathetic inputs regulate adaptive thermogenesis in brown adipose tissue through cAMP-Salt inducible kinase axis

@article{Paulo2018SympatheticIR,
  title={Sympathetic inputs regulate adaptive thermogenesis in brown adipose tissue through cAMP-Salt inducible kinase axis},
  author={Esther Paulo and Dongmei Wu and Yangmeng Wang and Yun Zhang and Yixuan Wu and Danielle L. Swaney and Margaret Soucheray and David Jimenez-Morales and A. S. Chawla and Nevan J. Krogan and Biao Wang},
  journal={Scientific Reports},
  year={2018},
  volume={8}
}
Various physiological stimuli, such as cold environment, diet, and hormones, trigger brown adipose tissue (BAT) to produce heat through sympathetic nervous system (SNS)- and β-adrenergic receptors (βARs). The βAR stimulation increases intracellular cAMP levels through heterotrimeric G proteins and adenylate cyclases, but the processes by which cAMP modulates brown adipocyte function are not fully understood. Here we described that specific ablation of cAMP production in brown adipocytes led to… Expand
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