Sympathetic inhibition and vasopressin mediation during centrally induced responses to serotonin in rats.

@article{Inoue1989SympatheticIA,
  title={Sympathetic inhibition and vasopressin mediation during centrally induced responses to serotonin in rats.},
  author={Atsushi Inoue and Ruben D Bu{\~n}ag},
  journal={Journal of cardiovascular pharmacology},
  year={1989},
  volume={13 6},
  pages={902-7}
}
To study mechanisms underlying the cardiovascular effects of centrally administered serotonin, we recorded responses to intracerebroventricular (i.c.v.) injections of serotonin in urethane-anesthetized rats. Dose-related increases in blood pressure accompanied by reductions in heart rate and sympathetic nerve firing were elicited consistently. The diminution in sympathetic nerve activity implies that while sympathetic inhibition could contribute to the bradycardia, sympathetic activation alone… CONTINUE READING

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