Sympathetic activation restrains endothelium-mediated muscle vasodilatation in heart failure patients.

@article{Santos2005SympatheticAR,
  title={Sympathetic activation restrains endothelium-mediated muscle vasodilatation in heart failure patients.},
  author={Amilton Cesar Santos and Maria Janieire de Nazar{\'e} Nunes Alves and Maria Urbana P B Rondon and Antonio Carlos Pereira Barretto and Holly R. Middlekauff and Carlos Eduardo Negr{\~a}o},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2005},
  volume={289 2},
  pages={
          H593-9
        }
}
Although the vasodilatory response during mental stress is blunted in heart failure (HF), the mechanisms underlying this phenomenon are not fully understood. We tested the hypothesis that sympathetic activity limits the endothelium-dependent vasodilatation during mental stress in chronic HF patients. Twenty-one HF patients (age 45 +/- 2 yr, functional classes III and IV, New York Heart Association) and 22 age-matched normal controls (NC; age 42 +/- 2 yr, P = 0.13) were studied at rest and… CONTINUE READING

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