Sympathetic activation of leptin via the ventromedial hypothalamus: leptin-induced increase in catecholamine secretion.

@article{Satoh1999SympatheticAO,
  title={Sympathetic activation of leptin via the ventromedial hypothalamus: leptin-induced increase in catecholamine secretion.},
  author={Naotake Satoh and Yoshihiro Ogawa and Goro Katsuura and Yukiko Numata and Takahiro Tsuji and Minoru Hayase and Ken Ebihara and Hiroaki Masuzaki and Kiminori Hosoda and Yasunao Yoshimasa and Kazuwa Nakao},
  journal={Diabetes},
  year={1999},
  volume={48 9},
  pages={1787-93}
}
Leptin is an adipocyte-derived blood-borne satiety factor that acts directly on the hypothalamus, thereby regulating food intake and energy expenditure. We have demonstrated that the hypothalamic arcuate nucleus (Arc) is a primary site of the satiety effect of leptin (Neurosci Lett 224:149-152, 1997). To explore the hypothalamic pathway of sympathetic activation of leptin, we examined the effects of a single intravenous or intracerebroventricular injection of recombinant human leptin on… CONTINUE READING