Sympathetic activation in chronic renal failure.

@article{Schlaich2009SympatheticAI,
  title={Sympathetic activation in chronic renal failure.},
  author={Markus P. Schlaich and Flora Socratous and Sarah C. Hennebry and Nina Eikelis and Elisabeth A. Lambert and Nora E. Straznicky and Murray D Esler and Gavin W. Lambert},
  journal={Journal of the American Society of Nephrology : JASN},
  year={2009},
  volume={20 5},
  pages={
          933-9
        }
}
The potential involvement of sympathetic overactivity has been neglected in this population despite accumulating experimental and clinical evidence suggesting a crucial role of sympathetic activation for both progression of renal failure and the high rate of cardiovascular events in patients with chronic kidney disease. The contribution of sympathetic neural mechanisms to the occurrence of cardiac arrhythmias, the development of hypertension, and the progression of heart failure are well… 
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The Sympathetic Nervous System in Chronic Kidney Disease

Current knowledge of the role of the sympathetic nervous system in the development and progression of CKD will be summarized, and novel treatment options targeting sympathetic nervousSystem activity will be discussed.

[Sympathetic nerve activity in chronic renal failure - what are the therapeutic options?].

Therapeutic options for hypertensive patients with chronic renal failure with respect to their sympathetic overactivity are inhibitors of the renin-angiotensin-system and central sympatholytic drugs.

Chronic kidney disease: role of sympathetic nervous system activation and potential benefits of renal denervation.

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Preliminary data to suggest that this approach can also be applied safely in patients with stage 3-4 CKD, and if appropriately designed clinical trials can confirm these initial observations, renal denervation may become a valuable new treatment option for the large cohort of patients with CKD.

Sympathetic nervous system: role in hypertension and in chronic kidney disease

Recent findings indicate that the metabolic disarray frequently complicating the high blood pressure state (metabolic syndrome, dislipidemia, insulin resistance) may have as pathophysiological background a sympathetic overdrive.

Sympathetic activation secondary to chronic kidney disease: therapeutic target for renal denervation?

The potential importance of RDN for patients with chronic kidney disease (CKD) is discussed, and the role of the kidneys as both generators and recipients of sympathetic hyperactivity is described.

Renal Denervation: Potential Future Implications Beyond Resistant Hypertension

Preliminary data obtained from small and mostly uncontrolled studies in related disease states often characterised by over-activity of the SNS are promising but require confirmation in appropriately designed clinical trials.

The Role of Renal Denervation in the Treatment of Heart Failure

A novel catheter-based device has recently been introduced that specifically interrupts both efferent and afferent renal nerves, and there is significant interest in the use of this device to treat both hypertension and CHF.

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    Journal of cardiovascular pharmacology and therapeutics
  • 2016
The potential role of catheter-based renal denervation in patients with impaired kidney function is discussed and the potential impact on other cardiovascular conditions commonly associated with chronic kidney disease such as heart failure and arrhythmias is reflected.

Sympathetic Activation in Hypertensive Chronic Kidney Disease – A Stimulus for Cardiac Arrhythmias and Sudden Cardiac Death?

The role of the feedback loop of the sympathetic neural cycle in the context of CKD and how it may aggravate several of the risk factors responsible for causing SCD is revisited.

Cardiovascular Disease in Chronic Kidney Disease

  • M. SarnakD. Weiner
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    Chronic Kidney Disease, Dialysis, and Transplantation
  • 2019
...

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