Sympathetic Release of Splenic Monocytes Promotes Recurring Anxiety Following Repeated Social Defeat.

@article{Mckim2016SympatheticRO,
  title={Sympathetic Release of Splenic Monocytes Promotes Recurring Anxiety Following Repeated Social Defeat.},
  author={Daniel B Mckim and Jenna M Patterson and Eric S. Wohleb and Brant L. Jarrett and Brenda F. Reader and Jonathan P. Godbout and John F Sheridan},
  journal={Biological psychiatry},
  year={2016},
  volume={79 10},
  pages={803-813}
}
BACKGROUND Neuroinflammatory signaling may contribute to the pathophysiology of chronic anxiety disorders. Previous work showed that repeated social defeat (RSD) in mice promoted stress-sensitization that was characterized by the recurrence of anxiety following subthreshold stress 24 days after RSD. Furthermore, splenectomy following RSD prevented the recurrence of anxiety in stress-sensitized mice. We hypothesize that the spleen of RSD-exposed mice became a reservoir of primed monocytes that… CONTINUE READING
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