Sympathetic Nervous System Dysfunction in Fibromyalgia, Chronic Fatigue Syndrome, Irritable Bowel Syndrome, and Interstitial Cystitis: A Review of Case-Control Studies

@article{MartnezMartnez2014SympatheticNS,
  title={Sympathetic Nervous System Dysfunction in Fibromyalgia, Chronic Fatigue Syndrome, Irritable Bowel Syndrome, and Interstitial Cystitis: A Review of Case-Control Studies},
  author={L. A. Mart{\'i}nez-Mart{\'i}nez and T. Polanco Mora and Ang{\'e}lica Vargas and Mario Fuentes-Iniestra and Manuel Mart{\'i}nez-Lav{\'i}n},
  journal={JCR: Journal of Clinical Rheumatology},
  year={2014},
  volume={20},
  pages={146–150}
}
Background Fibromyalgia often coexists and overlaps with other syndromes such as chronic fatigue, irritable bowel syndrome, and interstitial cystitis. Chronic stress has been implicated in the pathogenesis of these illnesses. The sympathetic nervous system is a key element of the stress response system. Sympathetic dysfunction has been reported in these syndromes, raising the possibility that such dysautonomia could be their common clustering underlying pathogenesis. Objective The objective of… Expand
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References

SHOWING 1-10 OF 15 REFERENCES
Central sensitivity syndromes: a new paradigm and group nosology for fibromyalgia and overlapping conditions, and the related issue of disease versus illness.
  • M. Yunus
  • Medicine
  • Seminars in arthritis and rheumatism
  • 2008
TLDR
CSS seems to be a useful paradigm and an appropriate terminology for FMS and related conditions, and the disease-illness, as well as organic/non-organic dichotomy, should be rejected. Expand
Fibromyalgia: When Distress Becomes (Un)sympathetic Pain
TLDR
In fibromyalgia, distress could be converted into pain through forced hyperactivity of the sympathetic component of the stress response system. Expand
Norepinephrine-evoked pain in fibromyalgia. A randomized pilot study [ISRCTN70707830]
TLDR
Fibromyalgia patients have norepinephrine-evoked pain, and this finding supports the hypothesis that fibromyalgia may be a sympathetically maintained pain syndrome. Expand
Biology and therapy of fibromyalgia. Stress, the stress response system, and fibromyalgia
TLDR
Fibromyalgia is proposed to be a sympathetically maintained neuropathic pain syndrome, and genomic data support this contention, and autonomic dysfunction may also explain other fibromyalgia features not related to pain. Expand
A SCN9A gene-encoded dorsal root ganglia sodium channel polymorphism associated with severe fibromyalgia
TLDR
Preliminary results raise the possibility that some patients with severe FM may have a dorsal root ganglia sodium channelopathy, a disabling form of FM associated to a particular SCN9A sodium channel gene variant. Expand
Stress and symptoms in patients with interstitial cystitis: a life stress model.
TLDR
Higher levels of stress were related to greater pain and urgency in patients with IC but not in the controls, and the relationship of stress and these IC symptoms was stronger among patients with more severe disease. Expand
Adrenergic dysregulation and pain with and without acute beta-blockade in women with fibromyalgia and temporomandibular disorder.
TLDR
These findings support the hypothesis that both FMS and TMD may frequently involve dysregulation of beta-adrenergic activity that contributes to altered cardiovascular and catecholamine responses and to severity of clinical pain. Expand
Level of chronic life stress predicts clinical outcome in irritable bowel syndrome.
TLDR
The level of chronic life stress threat predicts the clinical outcome in most patients with IBS/FD, and was a powerful predictor of subsequent symptom intensity over time. Expand
Catechol-O-methyltransferase gene haplotypes in Mexican and Spanish patients with fibromyalgia
TLDR
There was an association between FM and the COMT haplotype previously associated with high pain sensitivity, and there was a significant association between three SNPs and the presence of FM when compared with healthy controls. Expand
Self-Critical Perfectionism, Stress Generation, and Stress Sensitivity in Patients with Chronic Fatigue Syndrome: Relationship with Severity of Depression
TLDR
Investigation of the relationship between self-critical perfectionism, the active generation of stress, stress sensitivity, and levels of depression in a sample of 57 patients diagnosed with CFS using an ecological momentary assessment approach showed that self- critical perfectionism was associated with the generation of daily hassles, which in turn predicted higher levels of Depression. Expand
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