Sympathectomy-Induced Immune Changes Are Not Abrogated by the Glucocorticoid Receptor Blocker RU-486

@article{Kruszewska1998SympathectomyInducedIC,
  title={Sympathectomy-Induced Immune Changes Are Not Abrogated by the Glucocorticoid Receptor Blocker RU-486},
  author={Barbara Kruszewska and David L. Felten and Suzanne Y. Stevens and Jan A. Moynihan},
  journal={Brain, Behavior, and Immunity},
  year={1998},
  volume={12},
  pages={181-200}
}
Removal of sympathetic noradrenergic input to the immune system by injection of 6-hydroxydopamine (6-OHDA) triggers increases in antigen-specific in vitro splenocyte proliferation and cytokine production in BALB/cJ and C57B1/6J mice. This examines the possible role of glucocorticoids in these previously reported changes. In both strains, chemical sympathectomy triggers an elevation of glucocorticoid levels immediately following injection of 6-OHDA, returning to normal within one to two days. In… Expand
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