Symmetry requirements for effective blocking of pore-forming toxins: comparative study with alpha-, beta-, and gamma-cyclodextrin derivatives.

@article{Yannakopoulou2011SymmetryRF,
  title={Symmetry requirements for effective blocking of pore-forming toxins: comparative study with alpha-, beta-, and gamma-cyclodextrin derivatives.},
  author={Konstantina Yannakopoulou and L{\'a}szl{\'o} Jicsinszky and Crysie Aggelidou and Nikolaos Mourtzis and Tanisha M. Robinson and Adiamseged Yohannes and Ekaterina M. Nestorovich and Sergey M. Bezrukov and Vladimir A. Karginov},
  journal={Antimicrobial agents and chemotherapy},
  year={2011},
  volume={55 7},
  pages={3594-7}
}
We compared the abilities of structurally related cationic cyclodextrins to inhibit Bacillus anthracis lethal toxin and Staphylococcus aureus α-hemolysin. We found that both β- and γ-cyclodextrin derivatives effectively inhibited anthrax toxin action by blocking the transmembrane oligomeric pores formed by the protective antigen (PA) subunit of the toxin, whereas α-cyclodextrins were ineffective. In contrast, α-hemolysin was selectively blocked only by β-cyclodextrin derivatives, demonstrating… CONTINUE READING