Symmetry observations in long nucleotide sequences: a commentary on the Discovery Note of Qi and Cuticchia

@article{Forsdyke2002SymmetryOI,
  title={Symmetry observations in long nucleotide sequences: a commentary on the Discovery Note of Qi and Cuticchia},
  author={Donald R. Forsdyke},
  journal={Bioinformatics},
  year={2002},
  volume={18 1},
  pages={
          215-7
        }
}
The relative quantities of bases in DNA were determined chemically many years before sequencing technologies permitted direct counting of bases. Apparently unaware of the rich literature on the topic, bioinformaticists are today rediscovering the 'wheels' of Chargaff, Wyatt and other biochemists. It follows from Chargaff's second parity rule (%A = %T, %G = %C for single stranded DNA) that the symmetries observed for the two pairs of complementary mononucleotide bases, should also apply to the… 

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Purine and pyrimidine bases have been estimated from the desoxyribonucleic acids of eleven insect viruses, and no general parallelism is evident between DNA composition and biological relationship.