Symmetry breaking in mouse oocytes requires transient F-actin meshwork destabilization.

  title={Symmetry breaking in mouse oocytes requires transient F-actin meshwork destabilization.},
  author={Jessica Azoury and Karen Wingman Lee and Virginie Georget and Pascale Hikal and Marie-H{\'e}l{\`e}ne Verlhac},
  volume={138 14},
Female meiotic divisions are extremely asymmetric, giving rise to a large oocyte and small degenerating polar bodies, keeping the maternal stores for further embryo development. This asymmetry is achieved via off-center positioning of the division spindle. Mouse oocytes have developed a formin-2-dependent actin-based spindle positioning mechanism that allows the meiotic spindle to migrate towards the closest cortex. Using spinning disk microscopy and FRAP analysis, we studied the changes in the… CONTINUE READING

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