Symmetry breaking in mouse oocytes requires transient F-actin meshwork destabilization.

@article{Azoury2011SymmetryBI,
  title={Symmetry breaking in mouse oocytes requires transient F-actin meshwork destabilization.},
  author={Jessica Azoury and Karen Wingman Lee and Virginie Georget and Pascale Hikal and Marie-H{\'e}l{\`e}ne Verlhac},
  journal={Development},
  year={2011},
  volume={138 14},
  pages={2903-8}
}
Female meiotic divisions are extremely asymmetric, giving rise to a large oocyte and small degenerating polar bodies, keeping the maternal stores for further embryo development. This asymmetry is achieved via off-center positioning of the division spindle. Mouse oocytes have developed a formin-2-dependent actin-based spindle positioning mechanism that allows the meiotic spindle to migrate towards the closest cortex. Using spinning disk microscopy and FRAP analysis, we studied the changes in the… CONTINUE READING

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From mouse egg to mouse embryo: polarities, axes, and tissues.

Annual review of cell and developmental biology • 2009

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