Symmetry at the active site of the ribosome: structural and functional implications.

@article{Agmon2005SymmetryAT,
  title={Symmetry at the active site of the ribosome: structural and functional implications.},
  author={Ilana Agmon and A. Zaytzev Bashan and Raz Zarivach and Ada Etil Yonath},
  journal={Biological chemistry},
  year={2005},
  volume={386 9},
  pages={
          833-44
        }
}
The sizable symmetrical region, comprising 180 ribosomal RNA nucleotides, which has been identified in and around the peptidyl transferase center (PTC) in crystal structures of eubacterial and archaeal large ribosomal subunits, indicates its universality, confirms that the ribosome is a ribozyme and evokes the suggestion that the PTC evolved by gene fusion. The symmetrical region can act as a center that coordinates amino acid polymerization by transferring intra-ribosomal signals between… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 48 CITATIONS

References

Publications referenced by this paper.
SHOWING 1-10 OF 53 REFERENCES

Similar Papers

Loading similar papers…