Symmetry and Size of Membrane Protein Polyhedral Nanoparticles.

  title={Symmetry and Size of Membrane Protein Polyhedral Nanoparticles.},
  author={Di Li and Osman Kahraman and Christoph A. Haselwandter},
  journal={Physical review letters},
  volume={117 13},
In recent experiments [T. Basta et al., Proc. Natl. Acad. Sci. U.S.A. 111, 670 (2014)] lipids and membrane proteins were observed to self-assemble into membrane protein polyhedral nanoparticles (MPPNs) with a well-defined polyhedral protein arrangement and characteristic size. We develop a model of MPPN self-assembly in which the preferred symmetry and size of MPPNs emerge from the interplay of protein-induced lipid bilayer deformations, topological defects in protein packing, and thermal… 

Figures from this paper



Self-assembled lipid and membrane protein polyhedral nanoparticles

MPPNs provide not only a starting point for the structural analysis of membrane proteins in a phospholipid environment, but their closed surfaces should facilitate studies in the presence of physiological transmembrane gradients, in addition to potential applications as drug delivery carriers or as templates for inorganic nanoparticle formation.

Origin of icosahedral symmetry in viruses.

This work presents a minimal model for equilibrium capsid structure, introducing an explicit interaction between protein multimers (capsomers) and shows that the model reproduces the main structures of viruses in vivo and important nonicosahedral structures observed in vitro.

Budding and vesiculation induced by conical membrane inclusions.

  • T. AuthG. Gompper
  • Biology
    Physical review. E, Statistical, nonlinear, and soft matter physics
  • 2009
An analytical model to study budding and vesiculation of the lipid bilayer membrane, which is based on the membrane bending energy and the translational entropy of the inclusions, and results agree well with those of recent computer simulations.

Aggregation and vesiculation of membrane proteins by curvature-mediated interactions

Membrane remodelling plays an important role in cellular tasks such as endocytosis, vesiculation and protein sorting, and in the biogenesis of organelles such as the endoplasmic reticulum or the

Viral self-assembly as a thermodynamic process.

A statistical thermodynamic model for viral self-assembly finds that icosahedral symmetry is not expected for viral capsids constructed from structurally identical protein subunits and that this symmetry requires (at least) two internal "switching" configurations of the protein.

Directional interactions and cooperativity between mechanosensitive membrane proteins

For the experimental model system of mechanosensitive ion channels, the approach predicts how directional elastic interactions affect the molecular structure, organization, and biological function of proteins in crowded membranes.

Microfluidic device for super-fast evaluation of membrane protein nanoparticle formation

A new microfluidic device is demonstrated to rapidly form membrane protein lipid nanoparticles in an extremely short period (seconds) and the authors believe that this new method will make a transformative impact on commercial applications in a variety of areas from biology to pharmacology.

A Continuum Method for Determining Membrane Protein Insertion Energies and the Problem of Charged Residues

This work develops a fully continuum method that circumvents both of these shortcomings by using elasticity theory to determine the shape of the deformed membrane and then subsequently uses this shape to carry out continuum electrostatics calculations.

Elastic Properties of Lipid Bilayers: Theory and Possible Experiments

  • W. Helfrich
  • Physics
    Zeitschrift fur Naturforschung. Teil C: Biochemie, Biophysik, Biologie, Virologie
  • 1973
A theory of the elasticity of lipid bilayers is proposed and it is argued that in the case of vesicles (= closed bilayer films) the only elasticity controlling nonspherical shapes is that of curvature.

Cell Model Approach to Membrane Mediated Protein Interactions(Frontiers in Nonequilibrium Physics-Fundamental Theory, Glassy & Granular Materials, and Computational Physics-)

Membrane-deforming proteins can interact through the curvature fields they create. In the case of many such proteins a cell model approach can be used to calculate the energy per protein and predict,