Symmetry and Size of Membrane Protein Polyhedral Nanoparticles.

  title={Symmetry and Size of Membrane Protein Polyhedral Nanoparticles.},
  author={Di Li and Osman Kahraman and Christoph A. Haselwandter},
  journal={Physical review letters},
  volume={117 13},
In recent experiments [T. Basta et al., Proc. Natl. Acad. Sci. U.S.A. 111, 670 (2014)] lipids and membrane proteins were observed to self-assemble into membrane protein polyhedral nanoparticles (MPPNs) with a well-defined polyhedral protein arrangement and characteristic size. We develop a model of MPPN self-assembly in which the preferred symmetry and size of MPPNs emerge from the interplay of protein-induced lipid bilayer deformations, topological defects in protein packing, and thermal… 

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