Symmetrical effects of amphetamine and alpha-flupenthixol on conditioned punishment and conditioned reinforcement: contrasts with midazolam

@article{Killcross1997SymmetricalEO,
  title={Symmetrical effects of amphetamine and alpha-flupenthixol on conditioned punishment and conditioned reinforcement: contrasts with midazolam},
  author={A. Simon Killcross and Barry J. Everitt and T W Robbins},
  journal={Psychopharmacology},
  year={1997},
  volume={129},
  pages={141-152}
}
Abstract In a test of conditioned punishment, saline-treated controls showed a moderate bias in responding away from a lever producing a response-contingent auditory conditioned stimulus (CS) that had been paired with mild footshock during training and towards a lever producing a neutral auditory CS. Systemic treatment with the indirect dopamine (DA) agonist amphetamine (0.25–1.0 mg/kg) produced a dose-dependent increase in the punishing effect of the aversive CS, whilst responding on the… CONTINUE READING

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