Symmetric cell division of the mouse zygote requires an actin network.

@article{Chew2012SymmetricCD,
  title={Symmetric cell division of the mouse zygote requires an actin network.},
  author={Ting Gang Chew and Chanchao Lorthongpanich and Wei Xia Ang and Barbara B Knowles and Davor Solter},
  journal={Cytoskeleton},
  year={2012},
  volume={69 12},
  pages={
          1040-6
        }
}
Positioning of the cleavage plane is regulated to ensure proper animal development. Most animal cells rely on the astral microtubules to position the mitotic spindle, which in turn specifies the cleavage plane. The mouse zygote lacks discernible astral microtubules but still divides symmetrically. Here, we demonstrate a cloud-like accumulation of F-actin surrounds the spindle in zygotes and when this actin network is disassembled, the spindle assumes an off-center position, and the resulting… CONTINUE READING
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