Sylysia 350/Eudragit S100 solid nanomatrix as a promising system for oral delivery of cyclosporine A.

@article{Dai2015Sylysia3S,
  title={Sylysia 350/Eudragit S100 solid nanomatrix as a promising system for oral delivery of cyclosporine A.},
  author={Wenbing Dai and Yulan Guo and Hua Zhang and Xueqing Wang and Qiang Zhang},
  journal={International journal of pharmaceutics},
  year={2015},
  volume={478 2},
  pages={718-25}
}
Cyclosporine A (CyA) is a poorly soluble peptide and the available preparation is the surfactant based Sandimmum Neoral(®). In this study, we developed a novel pH-sensitive nanomatrix system of CyA with medical-grade nanoporous silica and Eudragit(®) to enhance the oral absorption of CyA as well as to improve the potential nephrotoxicity caused by the… CONTINUE READING