Syk tyrosine kinase required for mouse viability and B-cell development

@article{Cheng1995SykTK,
  title={Syk tyrosine kinase required for mouse viability and B-cell development},
  author={Alec M. Cheng and Bruce Ronald Rowley and William Pao and Adrian C Hayday and Joseph Beene Bolen and Tony Pawson},
  journal={Nature},
  year={1995},
  volume={378},
  pages={303-306}
}
THE Syk cytoplasmic protein-tyrosine kinase has two amino-terminal SH2 domains and a carboxy-terminal catalytic domain1. Syk, and its close relative ZAP-70 (ref. 2), are apparently pivotal in coupling antigen- and Fc-receptors to downstream signalling events3,4. Syk associates with activated Fc receptors5, the T cell receptor complex6 and the B-cell antigen-receptor complex (BCR) in immature and mature B lymphocytes7. On receptor activation, the tandem SH2 domains of Syk bind dual… CONTINUE READING

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