Syk is involved in NLRP3 inflammasome-mediated caspase-1 activation through adaptor ASC phosphorylation and enhanced oligomerization.

@article{Lin2015SykII,
  title={Syk is involved in NLRP3 inflammasome-mediated caspase-1 activation through adaptor ASC phosphorylation and enhanced oligomerization.},
  author={Ying-Cing Lin and D Y Huang and J Wang and Yi-Ling Lin and Shie-Liang Hsieh and Kuo-Chin Huang and Wan-Wan Lin},
  journal={Journal of leukocyte biology},
  year={2015},
  volume={97 5},
  pages={825-835}
}
NLRP3 is the most crucial member of the NLR family, as it detects the existence of pathogen invasion and self-derived molecules associated with cellular damage. Several studies have reported that excessive NLRP3 inflammasome-mediated caspase-1 activation is a key factor in the development of diseases. Recent studies have reported that Syk is involved in pathogen-induced NLRP3 inflammasome activation; however, the detailed mechanism linking Syk to NLRP3 inflammasome remains unclear. In this… CONTINUE READING
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