Syk-dependent phosphorylation of microtubules in activated B-lymphocytes.

  title={Syk-dependent phosphorylation of microtubules in activated B-lymphocytes.},
  author={S Faruki and Robert L. Geahlen and David J. Asai},
  journal={Journal of cell science},
  volume={113 ( Pt 14)},
Syk is a protein-tyrosine kinase that is essential for B-lymphocyte development and B-cell signaling. Syk phosphorylates tubulin on tyrosine both in vitro and in intact lymphocytes. Here we show that (alpha)-tubulin present within the cytoskeletal microtubule network was phosphorylated in a Syk-dependent manner following the activation of B-cells by engagement of the B-cell antigen receptor or by treatment with the phosphotyrosine phosphatase inhibitor, pervanadate. Immunofluorescence staining… CONTINUE READING


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