Syk- and Lyn-dependent phosphorylation of Syk on multiple tyrosines following B cell activation includes a site that negatively regulates signaling.

@article{Keshvara1998SykAL,
  title={Syk- and Lyn-dependent phosphorylation of Syk on multiple tyrosines following B cell activation includes a site that negatively regulates signaling.},
  author={Lakhu M. Keshvara and Christina C Isaacson and Thomas M Yankee and Radmila Sarac and Marietta L. Harrison and Robert L. Geahlen},
  journal={Journal of immunology},
  year={1998},
  volume={161 10},
  pages={5276-83}
}
The Syk protein tyrosine kinase is an essential component of the B cell Ag receptor signaling pathway. Syk is phosphorylated on tyrosine following B cell activation. However, the sites that are modified and the kinases responsible for these modifications have yet to be determined. To approach this problem, we used a mapping strategy based on the electrophoretic separation of peptides on alkaline polyacrylamide gels to identify the tryptic phosphopeptides derived from metabolically labeled Syk… CONTINUE READING

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