• Corpus ID: 13024953

Syiiergism between Cyclopropenoid Fatty Acids and Chemical Carcinogens in Rainbow Trout (Salmo

  title={Syiiergism between Cyclopropenoid Fatty Acids and Chemical Carcinogens in Rainbow Trout (Salmo},
  author={D. J. W. Lee and Joseph H. Wales and James Lee Ayres and Russell O. Sinnhuber},
SUMMARY The synergistic activities of cyclopropenoid fatty acids (CPFA), epoxyoleic acid, sesame seed oil, and autoxidized salmon oil with aflatoxin Bt were studied in rainbow trout. Sterculia foetida oil (49% sterculic, 7% malvalic acids) and Hibiscus syriacus oil (2% sterculic and 19% malvalic acids) were used as sources of CPFA. The combination of both 112 and 56 ppm CPFA procured from S, foetida oil and 210 ppm CPFA procured from H. syriacus oil promoted early tumor development, increased… 

Tables from this paper



Inhibition by cyclopropene fatty acids of the desaturation of stearic acid in hen liver

The results support the hypotheses that cyclopropene fatty acids inactivate an essential component of the desaturase system, probably by combination with-SH groups, and that this inhibition causes many of the effects of dietary cyclopropyrene fatty acids, including permeability disorders of eggs.

The effect of heated fat on the carcinogenic activity of 2-acetylaminofluorene.

The results indicated that the lipase-undigestible or the nonurea adduct-forming fraction isolated from heated oil acted in synergism with AAF and enhanced its carcinogenic activity.

Inhibition of the Desaturation of Stearic to Oleic Acid by Cyclopropene Fatty Acids

When hens and cows are fed on seed oils or concentrates of fatty acids containing cyclopropenoid compounds there is an increase in the stearic acid content and a decrease in the oleic acid Content of the lipids of the egg yolk and milk respectively.

The relationship of hepatoma in rainbow trout to aflatoxin contamination and cottonseed meal.

Results from other studies indicate that the naturally occurring cyclopropene fatty acids and gossypol in the cottonseed components probably enhanced the carcinogenic action of the minute quantity of aflatoxin.

Metabolism of the Carcinogen 2-Acetylaminofluorene by Rainbow Trout.∗

Summary Administration of the carcinogen 2-acetylaminofluorene (AAF) orally or by injection into rainbow trout resulted in the excretion of 5- and 7-hydroxy-AAF in the urine and feces. These


It was soon found that ingestion of other plants of the botanical order Malvales could also cause the appearance of pink whites in eggs, and later work was directed towards seeking the causes of the disorder among the plant products.

Methods for the determination of cyclopropenoid fatty acids V. A spectrophotometric method for cottonseed oils based upon the Halphen-test reaction

A spectrophotometric method of analysis for the quantitative estimation of cyclopropenoid fatty acids in cottonseed oil based upon the Halphen-test reaction has been described. Various parameters

Absence of aflatoxin from refined vegetable oils

The nonfluorescing forms of aflatoxins, capable of being produced during the alkali refining operations, are also absent from the refined vegetable oils; these aflatoxin derivatives are readily converted to their original form on acidification and thereby measurable by fluorescence, if present.

Development of Sarcomas in Marsh-Albino Mice Following Injection of Desoxycorticosterone Acetate in Sesame Oil.∗

  • E. MirandM. ReinhardH. L. Goltz
  • Biology, Medicine
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
  • 1953
Twenty-four mice of the Marsh-Albino strain were injected daily for a period of 3 months with desoxycorticosterone acetate in sesame oil, showing gross evidence of tumor formation, which became evident 6 months after completion of treatment.

Production of aflatoxin on rice.

A method has been developed for the production of aflatoxin by growing Aspergillus flavus strain NRRL 2999 on the solid substrate rice using chloroform-hexane mixtures.