Sydney Brenner. 13 January 1927—5 April 2019

  title={Sydney Brenner. 13 January 1927—5 April 2019},
  author={John White and Mark S. Bretscher},
From modest beginnings Sydney became an extraordinarily influential and accomplished molecular biologist. His critical knowledge of, and insights into, key scientific problems were legendary. His irrepressible personality, acerbic wit and ebullient talks inspired a generation of young biologists. He made seminal discoveries in how genetic information is used for protein synthesis, and established Caenorhabditis elegans as one of the foremost model organisms for the study of development and… 
2 Citations


The Cell in Development and Heredity
PROF. E. B. WILSON is the leading figure among the older American biologists—a rare combination of the scholarly mind with the adventurous research spirit. All who know him, whether personally or
History of research on C. elegans and other free-living nematodes as model organisms.
The pre-Brenner history of the use of free-living nematodes as models for general questions in biology is reviewed, focusing on the period that started in 1899 with the first publication of Emile Maupas mentioning Rhabditis elegans and ended in 1974 with thefirst publications by Brenner.
General Nature of the Genetic Code for Proteins
A very elegant series of genetic experiments by which Crick, Brenner, and their collaborators proved that the genetic code for protein was a triplet code using an acridine dye to induce mutations in a specific, well-studied gene of a virus that attacked the bacterium Escherichia coli.
This is in several ways a remarkable book, for it gives in one volume a competent comprehensive survey of the whole of biology—physiological, morphological, embryological, and evolutionary; it is written so that it can be ‘understanded of the people’ and with a sparkle that engages the attention.
Genomics in C. elegans: so many genes, such a little worm.
The Caenorhabditis elegans genome sequence is now complete, fully contiguous telomere toTelomere and totaling 100,291,840 bp, providing a solid platform on which to build toward a true molecular understanding of worm biology with all its implications including those for human health.
Sequences and consequences
  • S. Brenner
  • Biology
    Philosophical Transactions of the Royal Society B: Biological Sciences
  • 2010
It is proposed that the correct level of abstraction is the cell and the outline of Cellmap, a design for a system to organize biological information is provided, to solve the forward problem of computing the behaviour of the system from its components and their interactions.
The octopus genome and the evolution of cephalopod neural and morphological novelties
Coleoid cephalopods (octopus, squid and cuttlefish) are active, resourceful predators with a rich behavioural repertoire. They have the largest nervous systems among the invertebrates and present
Suppression of mutations in the alkaline phosphatase structural cistron of E. coli.
  • A. Garen, O. Siddiqi
  • Biology
    Proceedings of the National Academy of Sciences of the United States of America
  • 1962
"I Yanofsky, C., and P. R. Maling, Cellular Regulatory Mechanisms, Cold Spring Harbor Symposia on Quantitative Biology, vol.
Characterization of the pufferfish (Fugu) genome as a compact model vertebrate genome
The characterization of the small genome (400 Mb) of the tetraodontoid fish, Fugu rubripes, shows that the haploid genome contains 400 Mb of DNA, of which more that 90% is unique.
The DNA of Caenorhabditis elegans.
Chemical analysis and a study of renaturation kinetics show that the nematode, Caenorhabditis elegans, has a haploid DNA content of 8 x 10(7) base pairs (20 times the genome of E. coli). Eighty-three