Sydney Brenner

@article{Friedberg2008SydneyB,
  title={Sydney Brenner},
  author={Errol C. Friedberg},
  journal={Nature Reviews Molecular Cell Biology},
  year={2008},
  volume={9},
  pages={8-9}
}
  • E. Friedberg
  • Published 2008
  • Biology
  • Nature Reviews Molecular Cell Biology
Sydney Brenner was born in 1927 in South africa, where he attended medical school. he obtained his DPhil from Oxford University, UK, and spent most of his professional career at the Laboratory of Molecular Biology at Cambridge University, UK, working with the late Francis Crick for much of that time. Brenner won the nobel Prize in 2002 for establishing Caenorhabditis elegans as the widely used experimental model it is today. he presently divides his time between Cambridge, the Salk institute… 
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18 Citations

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Fruit Flies in Biomedical Research
TLDR
Drosophila is an excellent model organism for studies that have translational impact for genetic disease and for other medical implications such as vector-borne illnesses, and a better collaboration between DrosophILA geneticists/biologists and human geneticist/bioinformaticians/clinicians is promoted.
The brave new era of human genetic testing.
The commercialization of 'big science' is in full swing, leading to situations in which the ethical principles of academia are beginning to be compromised. This is exemplified by the profitable…
The fall and rise of pharmacology--(re-)defining the discipline?
A novel in vitro Caenorhabditis elegans transcription system
TLDR
An in vitro C. elegans transcription system that re-constitutes transcription reactions with nuclear extract of larval or adult worms and can both qualitatively and quantitatively detect transcription activity using non-radioactive approaches is developed.
Faraway, so close. The comparative method and the potential of non-model animals in mitochondrial research
TLDR
The dominance of the mechanistic/reductionist approach in life sciences is discussed and a case for an enhanced application of the comparative approach to study processes in all their various forms across different organisms is made.
The cycle of genome-directed medicine
TLDR
The genome era in medicine is upon us and medical infrastructure needs to adapt to the dramatic pace of technology development in the wake of the Human Genome Project, in order for genome data to be delivered as information and applied as knowledge to benefit health.
Systems Biology — the Broader Perspective
TLDR
It is argued that the natural language for systems-biological descriptions of biological phenomena is the mathematical graph, which not only integrates events at different levels but emphasize the distributed nature of control as well as displaying a great deal of data.
The Circuit Architecture of Whole Brains at the Mesoscopic Scale
Unknown unknowns in biomedical research: does an inability to deal with ambiguity contribute to issues of irreproducibility?
Translational paradigms in pharmacology and drug discovery.
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