Syd, a SecY-interacting protein, excludes SecA from the SecYE complex with an altered SecY24 subunit.

@article{Matsuo1998SydAS,
  title={Syd, a SecY-interacting protein, excludes SecA from the SecYE complex with an altered SecY24 subunit.},
  author={Ei-ichi Matsuo and Hirotada Mori and Takashi Shimoike and Koreaki Ito},
  journal={The Journal of biological chemistry},
  year={1998},
  volume={273 30},
  pages={18835-40}
}
Syd is an Escherichia coli cytosolic protein that interacts with SecY. Overproduction of this protein causes a number of protein translocation-related phenotypes, including the strong toxicity against the secY24 mutant cells. Previously, this mutation was shown to impair the interaction between SecY and SecE, the two fundamental subunits of the membrane-embedded part of protein translocase. We have now studied in vitro the mechanisms of the Syd-directed inhibition of protein translocation. Pro… CONTINUE READING