Sws1 is a conserved regulator of homologous recombination in eukaryotic cells.

@article{Martin2006Sws1IA,
  title={Sws1 is a conserved regulator of homologous recombination in eukaryotic cells.},
  author={Victoria L Martin and Charly Chahwan and Hui Gao and V{\'e}ronique Blais and James A Wohlschlegel and John R. Yates and Clare H. McGowan and Paul Russell},
  journal={The EMBO journal},
  year={2006},
  volume={25 11},
  pages={2564-74}
}
Rad52-dependent homologous recombination (HR) is regulated by the antirecombinase activities of Srs2 and Rqh1/Sgs1 DNA helicases in fission yeast and budding yeast. Functional analysis of Srs2 in Schizosaccharomyces pombe led us to the discovery of Sws1, a novel HR protein with a SWIM-type Zn finger. Inactivation of Sws1 suppresses the genotoxic sensitivity of srs2Delta and rqh1Delta mutants and rescues the inviability of srs2Delta rqh1Delta cells. Sws1 functions at an early step of… CONTINUE READING

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