Swm1/Apc13 is an evolutionarily conserved subunit of the anaphase-promoting complex stabilizing the association of Cdc16 and Cdc27.

@article{Schwickart2004Swm1Apc13IA,
  title={Swm1/Apc13 is an evolutionarily conserved subunit of the anaphase-promoting complex stabilizing the association of Cdc16 and Cdc27.},
  author={Martin Schwickart and Jan Havlis and Bianca H Habermann and Aliona Bogdanova and Alain Camasses and Tobias Oelschlaegel and Andrej Shevchenko and W. Zachariae},
  journal={Molecular and cellular biology},
  year={2004},
  volume={24 8},
  pages={3562-76}
}
The anaphase-promoting complex (APC/C) is a large ubiquitin-protein ligase which controls progression through anaphase by triggering the degradation of cell cycle regulators such as securin and B-type cyclins. The APC/C is an unusually complex ligase containing at least 10 different, evolutionarily conserved components. In contrast to APC/C's role in cell cycle regulation little is known about the functions of individual subunits and how they might interact with each other. Here, we have… CONTINUE READING

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