Switching to hypomania and mania: differential neurochemical, neuropsychological, and pharmacologic triggers and their mechanisms.

@article{Chen2010SwitchingTH,
  title={Switching to hypomania and mania: differential neurochemical, neuropsychological, and pharmacologic triggers and their mechanisms.},
  author={Jun Chen and Yi-ru Fang and David Eric Kemp and Joseph R. Calabrese and Keming Gao},
  journal={Current psychiatry reports},
  year={2010},
  volume={12 6},
  pages={512-21}
}
Current data suggest that monoamines, acetylcholine, amino acids, cortisol, thyroid hormones, and melatonin may be involved in the pathophysiology of bipolar disorder (BPD). Any neuropsychological or pharmacologic factor causing a disturbance in these neurochemicals may trigger manic/hypomanic switching. Antidepressants, stimulants, anticholinergics, steroids, and thyroid hormone have been reported to cause treatment-emergent mania (TEM) in BPD, but only recently have the traditional… CONTINUE READING

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