Switching the mechanism of mating type switching: a domesticated transposase supplants a domesticated homing endonuclease.

@article{Rusch2010SwitchingTM,
  title={Switching the mechanism of mating type switching: a domesticated transposase supplants a domesticated homing endonuclease.},
  author={Laura N. Rusch{\'e} and Jasper Rine},
  journal={Genes & development},
  year={2010},
  volume={24 1},
  pages={
          10-4
        }
}
Programmed DNA rearrangements are critical for the development of many organisms and, intriguingly, can be catalyzed by domesticated mobile genetic elements. In this issue of Genes & Development, Barsoum and colleagues (pp. 33-44) demonstrate that, in the budding yeast Kluyveromyces lactis, a DNA rearrangement associated with mating type switching requires a domesticated transposase and occurs through a mechanism distinct from that in the related yeast, Saccharomyces cerevisiae. Thus… CONTINUE READING
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