Corpus ID: 28719026

Switching the in vivo specificity of a minimal Hox-responsive element.

@article{Chan1997SwitchingTI,
  title={Switching the in vivo specificity of a minimal Hox-responsive element.},
  author={S. Chan and H. Ryoo and A. Gould and R. Krumlauf and R. Mann},
  journal={Development},
  year={1997},
  volume={124 10},
  pages={
          2007-14
        }
}
The homeodomain proteins encoded by the Hox complex genes do not bind DNA with high specificity. In vitro, Hox specificity can be increased by binding to DNA cooperatively with the homeodomain protein extradenticle or its vertebrate homologs, the pbx proteins (together, the PBC family). Here we show that a two basepair change in a Hox-PBC binding site switches the Hox-dependent expression pattern generated in vivo, from labial to Deformed. The change in vivo correlates with an altered Hox… Expand
Functional characterisation of a HOX/PBX transcriptional complex
Activity regulation of a Hox protein and a role for the homeodomain in inhibiting transcriptional activation
Regulation of Hox target genes by a DNA bound Homothorax/Hox/Extradenticle complex.
Synergistic activation of a Drosophila enhancer by HOM/EXD and DPP signaling
Hox cofactors in vertebrate development.
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