Switching on-off Snail: LOXL2 versus GSK3beta.

@article{Peinado2005SwitchingOS,
  title={Switching on-off Snail: LOXL2 versus GSK3beta.},
  author={H{\'e}ctor Peinado and Francisco Portillo and A Barbado Cano},
  journal={Cell cycle},
  year={2005},
  volume={4 12},
  pages={1749-52}
}
Epithelial-mesenchymal transition (EMT) is considered as an essential determinant of carcinoma progression. The transcription factor Snail controls EMT by repressing E-cadherin gene expression and other epithelial genes. Snail protein stability and cellular localization is finely controlled by GSK3beta-dependent phosphorylation and subsequent ubiquitination. GSK3beta phosphorylates Snail at two different motifs which induce its nuclear export and association with beta-Trcp thus leading to Snail… CONTINUE READING

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