Switching on RNA silencing suppressor activity by restoring argonaute binding to a viral protein.

Abstract

We found that Sweet potato feathery mottle virus (SPFMV) P1, a close homologue of Sweet potato mild mottle virus P1, did not have any silencing suppressor activity. Remodeling the Argonaute (AGO) binding domain of SPFMV P1 by the introduction of two additional WG/GW motifs converted it to a silencing suppressor with AGO binding capacity. To our knowledge… (More)
DOI: 10.1128/JVI.00627-12

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