Switching of dominant retrotransposon silencing strategies from posttranscriptional to transcriptional mechanisms during male germ-cell development in mice

@inproceedings{Inoue2017SwitchingOD,
  title={Switching of dominant retrotransposon silencing strategies from posttranscriptional to transcriptional mechanisms during male germ-cell development in mice},
  author={Kota Inoue and Kenji Ichiyanagi and Kei Fukuda and Michael Glinka and Hiroyuki Sasaki},
  booktitle={PLoS genetics},
  year={2017}
}
Mammalian genomes harbor millions of retrotransposon copies, some of which are transpositionally active. In mouse prospermatogonia, PIWI-interacting small RNAs (piRNAs) combat retrotransposon activity to maintain the genomic integrity. The piRNA system destroys retrotransposon-derived RNAs and guides de novo DNA methylation at some retrotransposon promoters… CONTINUE READING